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CD74 is expressed on the floor of renal tubular epithelial cells. Also, these cells Convey minimal levels of MIF that's elevated next AKI to make sure sufficient provides at the site of damage (80, eighty one). A spontaneous pathological renal phenotype is absent MIF knock-out mice, suggesting small to no effect on nutritious organs (eighty two). n
Atherosclerosis is accelerated in individuals with inflammatory conditions and You can find increasing proof that it may be further more exacerbated by glucocorticoid cure. A speedily increasing amount of literature implies that MIF is implicated in the pathogenesis of sepsis, and inflammatory and autoimmune conditions, suggesting that MIF-directe